New words：

avail [ə'veil] v.有用；有帮助；有益
to no/little avail 没有什么效果；不成功
of no/little avail 没有什么用处；没有用

Sample Sentences：

This medicine is of no avail.
We tried to keep him alive but to no avail.
The medicine did not avail against the disease.
He tried and tried but all his efforts were of no avail.

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